Dihexa / Methylene Blue / Tesofensine blend (oral)

This is a combination capsule holding three compounds at fixed amounts: Dihexa 5 mg, Methylene Blue 50 mg, and Tesofensine 500 mcg. A mcg is a microgram, one thousandth of a milligram (mg).

Dihexa (also written N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, or PNB-0408) is a nootropic — a compound taken to improve thinking. It was developed for Alzheimer's and Parkinson's disease, and is also said to improve stroke recovery, speeds recovery from spinal cord and nerve injury, and protects against hearing loss. What makes it unusual is that it does not just slow damage down; it repairs the synapse, the junction where one nerve cell passes a signal to the next. It works by binding HGF (hepatocyte growth factor), a signalling protein that drives cell growth and repair, increasing its activity while lowering harmful chemical reactions — which is said to double what the growth factors already present can do.

Methylene Blue (methylthioninium chloride) is a synthetic dye long used as a stain in laboratories and in many industrial and medical applications. The World Health Organization has it on its List of Essential Medicines, meaning it is considered vital for a basic health system. Inside cells it can carry electrons through the energy-producing chain in mitochondria — the tiny structures that turn food into usable energy — bypassing faults in that chain.

Tesofensine (NS2330) is a triple reuptake inhibitor. Nerve cells communicate using chemical messengers; after a message is sent, the cell normally reabsorbs the messenger. Tesofensine blocks that reabsorption for three of them — serotonin, norepinephrine, and dopamine — so more remains active. It was first researched as an add-on for Alzheimer's treatment and became known as a weight loss drug once its effects on weight became clear. It is reported to produce an average 10% weight loss within 24 weeks, and to raise blood pressure by 1 to 3 mmHg (millimetres of mercury, the unit blood pressure is measured in) and heart rate by up to 8 beats per minute.

Read the who-should-avoid section before you take this. Methylene Blue blocks an enzyme called MAO-A. Tesofensine must not be used with MAO inhibitors. Both are in this capsule, and that conflict has not been resolved.

Three different things at once, which is the point of the combination.

Dihexa builds new connections between brain cells, improving memory and learning, and raises production of acetylcholine and dopamine — two of the chemical messengers nerve cells use. It also protects nerve cells and increases blood flow to the brain.

Methylene Blue improves how mitochondria produce energy, acts as an antioxidant (neutralising free radicals, the unstable molecules that damage cells), adjusts nitric oxide levels which affects blood flow, protects nerve cells, increases blood flow to the brain, and disrupts the workings of bacteria and other microbes.

Tesofensine raises serotonin, norepinephrine, and dopamine. That drives appetite suppression and weight loss, but also affects mood, energy, sleep, and blood sugar.

So the combination is: build the brain's wiring, power the cells that wiring runs on, and turn up the messengers travelling through it — with weight loss as the third compound's main effect.

The practical instruction is one capsule in the morning, best taken with a light meal containing a small amount of protein and fat, avoiding heavy carbohydrates.

One capsule per day, in the morning. Each capsule holds Dihexa 5 mg, Methylene Blue 50 mg, and Tesofensine 500 mcg.

It is best taken with a light meal containing a small amount of protein and fat, and to avoid heavy carbohydrates. That differs from every one of the three standalone pages: Dihexa says take it on an empty stomach, and Methylene Blue says lightly fasted.

There is no build-up. You start at the full dose of all three compounds on day one.

No cycle length or washout period has been established for this blend. For comparison, the standalone pages run 8 to 12 weeks for Dihexa and 4 to 8 weeks for Methylene Blue.

Two dose comparisons worth knowing. The Methylene Blue here is 50 mg, double the 25 mg on the standalone Methylene Blue page. The Dihexa at 5 mg is the lowest dose on its own page's 5 to 20 mg range, and the Tesofensine at 500 mcg matches its standalone page exactly.